Abstract Deubiquitinases (DUBs) are enzymes that control the stability, interactions or localization of most cellular proteins by removing their ubiquitin modification.In recent years, some DUBs, such as USP7, USP9X and C-Safe Board USP10, have been identified as promising therapeutic targets in hematological malignancies.Importantly, some potent i
Abstract Background The pathogenic mechanism of dilated cardiomyopathy (DCM) remains to be defined.This study aimed to identify hub genes and immune cells that could serve as potential therapeutic targets for DCM.Methods We downloaded four datasets from the Gene Expression Omnibus (GEO) database: GSE141910, GSE3585, GSE42955 and GSE79962.Weighted g
Studies of homozygous PAR2 gene knockout mice have described a mix of phenotypic effects in vitro and in vivo.However, there have been few studies of PAR2 heterozygous (wild-type/knockout; PAR2-HET) mice.The phenotypes of many hemi and heterozygous transgenic mice have been described as intermediates between those of wild-type and knockout Bachelor
Abstract Introduction Indigenous people of different ethnic groups in Ethiopia are noticeably reliant on traditional medicinal plants for their healthcare due to their effective medicinal values.The study was aimed to document different herbal medicinal plants used and the associated knowledge of herbal medicine in the communities of the Artuma Fur
The preference-performance hypothesis explains host specificity in phytophagous insects, positing that host plants chosen by adults confer the greatest larval fitness.However, adults sometimes oviposit on plants supporting low larval success because the components of host specificity (adult preference, plant palatability, and larval survival) are n